Animal Research Benefits CF Sufferers

Pigs Yield Clues to Cystic Fibrosis-Related Lung Disease
Infection appears to precede inflammation, researchers find

WEDNESDAY, April 28 (HealthDay News) -- Researchers say they have answered a long-standing question regarding lung disease caused by cystic fibrosis: Which comes first, infection or inflammation?

"Using our model, we are beginning to answer that question, and it looks like infection does precede inflammation," study author Dr. David Stoltz, an assistant professor of internal medicine at the University of Iowa, said in a news release from the school. "The importance of that finding is that it could dictate what types of therapy we might use. Knowing that infection is first suggests that if we can prevent or fight infection, then that might delay or prevent the lung disease in people with CF."

Most of the deaths and disability in people with CF result from lung disease.

The findings also appear to suggest that lung infections in children with cystic fibrosis should be treated early and aggressively, Stoltz said.

The researchers reached their conclusions by studying pigs with a genetic mutation that causes cystic fibrosis.

"This is a really great example where the pig serves as a model for what happens in the human, and the pig reacts to this disease in nearly the same way," study co-author Randall Prather, distinguished professor of reproductive biotechnology at the University of Missouri, said in the news release. "In contrast, when you use mice, they don't get the lung disease that is common in patients with cystic fibrosis."

The study was published online April 28 in the journal Science Translational Medicine. Link

On a daily basis, we see medical advances from the use of animals in research. The people whose lives have been affected by CF certainly are complaining about the use of pigs in this study. Unfortunately there are elitists in our society that believe the gains in scientific knowledge about this crippling disease weren’t worth using a pig. They don’t place any more value on the life of sick child than they do a pig. Luckily, for all of us, these scientists continue working hard to find a cure.

Pigs Helping Kids

Researchers Develop Pig Model for Cystic Fibrosis
Now they can track disease progression as it happens, something not possible in humans
Posted September 26, 2008

FRIDAY, Sept. 26 (HealthDay News) -- Researchers say they have developed a model for cystic fibrosis (CF) in piglets that may help improve understanding of the disease in human infants and help in the discovery of new treatments.

The finding, by researchers at the University of Iowa and the University of Missouri, was published in the Sept. 26 issue of Science.

Cystic fibrosis, a common hereditary disease, affects multiple organ systems, including the intestines, pancreas and lungs. A primary cause of death and disability in these patients is lung disease. Researchers have previously studied mice with CF-causing mutations to study the disease, but the mice do not develop many of the typical symptoms that affect humans.

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My wife and I have been blessed with three healthy children, but not every parent has received those same blessings. Using pigs to better understand a disease like cystic fibrosis will hopefully lead to a cure. There will, no doubt, be people upset about using pigs for this type of research, but I would dare them to look into the eyes of a parent with a sick child and try to do their complaining there.